The Human Upgrade

A wide-ranging conversation on the modern psychedelic landscape — how set, setting, and integration shape outcomes, why religious frameworks still matter, and what newcomers most often get wrong.


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TRANSCRIPT

From the conversation.

Matt joins Dave to discuss the practical realities of psychedelics in 2024 — what the research actually says, what it doesn't, and where the cultural conversation has gotten ahead of the evidence.

They cover the role of preparation and integration, the difference between recreational and ceremonial contexts, and why community care matters more than any single substance or protocol.

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The Joe Rogan Experience: Redefining Human Baseline